P-glycoprotein expression in retinoblastoma

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2005 English Publisher:BMJJournal:British Journal of Ophthalmology, volume 89, pages 784-784 (issn: 0007-1161,

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Authors: I J, Dunkel; D H, Abramson; C, Cordon-Cardo; G L, Chantada; M T G, de Davila; A C, Fandino;

doi: 10.1136/bjo.2005.068536

pmid: 15923533

pmc: PMC1772686

P-glycoprotein expression in retinoblastoma

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Abstract

We have read with interest the paper by Krishnakumar et al .1 We have studied 18 children with retinoblastoma using immunohistochemical detection of P-glycoprotein by the mouse monoclonal antibody HYB-241 in frozen section tumour samples. Like Krishnakumar et al , we found limited expression of P-glycoprotein in retinoblastoma cells since only four of the 18 samples were positive. However, six of 18 samples had P-glycoprotein positivity in tumour associated endothelial cells. Contrary to Krishnakumar et al , we had …

Keywords

Retinal Neoplasms, Retinoblastoma, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Child, Neoplasm Proteins

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