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BMJ Case Reports
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BMJ Case Reports
Article . 2018 . Peer-reviewed
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BMJ Case Reports
Article . 2018
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Blastic plasmacytoid dendritic cell neoplasm: a rare case of gingival lesion with leukaemic presentation

Authors: Viviano, Massimo; Cocca, Serena; Miracco, Clelia; Parrini, Stefano;

Blastic plasmacytoid dendritic cell neoplasm: a rare case of gingival lesion with leukaemic presentation

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare haematological malignancy with an aggressive clinical course. It has been recognised as a distinct entity in the WHO 2008 classification of haematolymphoid neoplasm. This disease usually presents with cutaneous involvement as the first manifestation, with subsequent or simultaneous spread to bone marrow and peripheral blood with leukaemic dissemination. Gingival lesion as the first manifestation, in the absence of a cutaneous lesion, is an uncommon presentation of this rare disease. We report a case of an elderly woman, aged 84 years, who presented with a lump on the mandibular gingiva and ipsilateral otalgia without any cutaneous lesion and associated with an highly aggressive and rapid leukaemia. This case is an addition to the handful of those cases of BPDCN which presents without cutaneous involvement, but it is exceedingly rare for clinical features that make it a unique case in the literature.

Country
Italy
Keywords

Aged, 80 and over, Skin Neoplasms, Medicine (all), Gingiva, 610, Pain, Dendritic Cells, Mandible, Leukemia, Plasma Cell, dentistry and oral medicine, Fatal Outcome, Rare Diseases, 616, Radiography, Panoramic, Humans, head and neck cancer, Female, dentistry and oral medicine; head and neck cancer; mouth; Medicine (all), mouth, Deglutition Disorders

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    3
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
bronze
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