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BMJ Case Reports
Article
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BMJ Case Reports
Article . 2014 . Peer-reviewed
Data sources: Crossref
BMJ Case Reports
Article . 2014
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Phenytoin-induced gingival enlargement

Authors: Lisa Neelathil, Chacko; Sathish, Abraham;

Phenytoin-induced gingival enlargement

Abstract

Gingival overgrowth occurs as a side effect of some systemic medications. It is now well established that phenytoin is one such agent. It has multiple therapeutic indications ranging from convulsive disorders and neuralgias to cardiac arrhythmia. The incidence rate of phenytoin-induced gingival overgrowth ranges from 3% to 93%, but 50% of patients on long-term therapy are prone to develop gingival overgrowth. This drug-induced overgrowth is noticed initially in the papillary region and during the course of the process involves the margins and the gingival attachment. As the tissue enlarges, it develops a characteristically lobulated and thickened appearance either partially or sometimes completely covering the tooth surfaces. The colour ranges from pink to a deep bluish red depending on the amount of inflammatory infiltrate present in the tissues and secondary inflammation may induce oedema, ulcerations and bleeding. The overgrowth takes 2–3 months to become noticeable and can take …

Keywords

Male, Treatment Outcome, Phenytoin, Gingival Hyperplasia, Humans, Anticonvulsants, Gingivectomy

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    16
    popularity
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    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Top 10%
Top 10%
Average
bronze