HHV-6 is ubiquitous in the community, appears to be acquired early in life, and has been proved to cause the clinical syndrome of exanthem subitum, and rarely to cause encephalitis. Like other herpesviruses, HHV-6 is capable of establishing latent infection and reactivating under a variety of stimuli. Improved diagnostic techniques have led to increased recognition of HHV-6 in the presence of many diseases, but much of the evidence for an aetiological role is inconclusive. There is accruing evidence for possible pathological roles in the immunocompromised host, but the evidence is less convincing for the range of associations otherwise listed for the normal host at the present time.