Microbial hydroxylation of some steroids by Aspergillus wentii MRC 200316

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2010 Turkey English Publisher:Institute of Organic Chemistry & BiochemistryJournal:Collection of Czechoslovak Chemical Communications, volume 75, pages 1,273-1,281 (eissn: 1212-6950,

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Authors: Yıldırım, Kudret;

doi: 10.1135/cccc2010112

handle: 20.500.12619/44780

Microbial hydroxylation of some steroids by Aspergillus wentii MRC 200316

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Abstract

Biotransformations of epiandrosterone (1), dehydroepiandrosterone (2) and pregnenolone (3) byAspergillus wentiiMRC 200316 for 5 days have been reported. Incubation of epiandrosterone (1) afforded 11α-hydroxy-5α-androstane-3,17-dione (4) and 3β,11α-dihydroxy-5α-androstan-17-one (5). Incubation of dehydroepiandrosterone (2) afforded 3β,7β-di-hydroxyandrost-5-en-17-one (6) and 3β,7α-dihydroxyandrost-5-en-17-one (7). Incubation of pregnenolone (3) afforded only 11α-hydroxypregn-4-ene-3,20-dione (8).

Country

Turkey

Related Organizations

Sakarya University
Turkey

Keywords

Chemistry

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