The synthesis of substituted 2H-1,2-benzothiazines 1,1-dioxides

Jiří Svoboda; Jaroslav Paleček; Václav Dědek

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Collection of Czechoslovak Chemical Communications

Article . 1986 . Peer-reviewed

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https://dx.doi.org/10.1135/ccc...

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The synthesis of substituted 2H-1,2-benzothiazines 1,1-dioxides

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 English Publisher:Institute of Organic Chemistry & BiochemistryJournal:Collection of Czechoslovak Chemical Communications, volume 51, pages 1,133-1,139 (issn: 0010-0765, eissn: 1212-6950,

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Authors: Jiří Svoboda; Jaroslav Paleček; Václav Dědek;

doi: 10.1135/cccc19861133

The synthesis of substituted 2H-1,2-benzothiazines 1,1-dioxides

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Abstract

The base-catalyzed rearrangement of the esters of 2H-1,2-benzothiazolin-3-one-2-acetate 1,1-dioxide (IIa - IIc) afforded substituted 2H-1,2-benzothiazine-3-carboxylate 1,1-dioxides IIIa -IIIc. After N-alkylation and aminolysis the antiinflammatory drugs piroxicam and isoxicam were obtained.

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