Mechanism of the Nrf2/Keap1/ARE signaling system
Copyright policy )Mechanism of the Nrf2/Keap1/ARE signaling system
Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis. These molecular patterns are in close interconnection and function as parts of the integrated redox-sensitive signaling system Nrf2/Keap1/ARE. Depending on cellular redox balance, activity of this signaling system changes at the levels of transcription, translation, posttranslational modification, nuclear translocation of transcription factor, and its binding to ARE-driven gene promoters. This review summarizes current conceptions of Nrf2/Keap1/ARE induction and inactivation.
- Siberian Branch of the Russian Academy of Sciences Russian Federation
- Russian Academy
Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Protein Conformation, Intracellular Signaling Peptides and Proteins, Gene Expression, Response Elements, Oxidative Stress, Gene Expression Regulation, Animals, Humans, Oxidation-Reduction, Signal Transduction
Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Protein Conformation, Intracellular Signaling Peptides and Proteins, Gene Expression, Response Elements, Oxidative Stress, Gene Expression Regulation, Animals, Humans, Oxidation-Reduction, Signal Transduction
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