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Sensitivity of Human Mastadenovirus, the Causal Agent of Pharyngoconjunctival Fever, Epidemic Keratoconjunctivitis, and Hemorrhagic Cystitis in Immunocompromised Individuals, to Brincidofovir

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 23 Feb 2022 English Publisher:American Society for MicrobiologyJournal:Microbiology Spectrum, volume 10 (eissn: 2165-0497, Copyright policy )
Authors: Nozomu Hanaoka; Masatoshi Hazama; Koji Fukushima; Tsuguto Fujimoto;

doi: 10.1128/spectrum.01569-21

pmid: 35171015

pmc: PMC8849070

Sensitivity of Human Mastadenovirus, the Causal Agent of Pharyngoconjunctival Fever, Epidemic Keratoconjunctivitis, and Hemorrhagic Cystitis in Immunocompromised Individuals, to Brincidofovir

Abstract

We investigated the IC 50 values of BCV for novel HAdV types and found that the epidemic keratoconjunctivitis-associated HAdV-D54 prevalent in the Asian region was the most susceptible. In addition, the mean overall IC 50 value of BCV was lower than that of CDV, indicating that BCV is effective against HAdVs.

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Keywords

Adenoviridae Infections, Keratoconjunctivitis, Organophosphonates, Observation, Microbiology, QR1-502, Adenovirus Infections, Human, half-maximal inhibitory concentration, Cytosine, Immunocompromised Host, Mastadenovirus, human mastadenovirus, Cystitis, Humans, brincidofovir, novel type

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 5
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Top 10%
Average
Top 10%
Green
gold
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