Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils
Copyright policy )Syndecan-1 Promotes Streptococcus pneumoniae Corneal Infection by Facilitating the Assembly of Adhesive Fibronectin Fibrils
Bacterial pathogens have evolved several ingenious mechanisms to subvert host cell biology for their pathogenesis. Bacterial attachment to the host ECM establishes a niche to grow and is considered one of the critical steps of infection. This pathogenic mechanism entails coordinated assembly of the ECM by the host to form the ECM structure and organization that are specifically recognized by bacteria for their adhesion. We serendipitously discovered that epithelial Sdc1 facilitates the assembly of FN fibrils in the corneal basement membrane and that this normal biological function of Sdc1 has detrimental consequences for the host in S. pneumoniae corneal infection. Our studies suggest that bacterial subversion of the host ECM is more complex than previously appreciated.
- Harvard Medical School United States
- Boston Children's Hospital United States
- University of Bristol United Kingdom
- Harvard University United States
- University of Bristol (UoB) United Kingdom
extracellular matrix, Fluorescent Antibody Technique, Gene Expression, Microbiology, Bacterial Adhesion, Cornea, Mice, host-pathogen interactions, Animals, Keratitis, Mice, Knockout, syndecans, Immunohistochemistry, QR1-502, Extracellular Matrix, Fibronectins, Disease Models, Animal, keratitis, Streptococcus pneumoniae, Gain of Function Mutation, Host-Pathogen Interactions, proteoglycans, Syndecan-1, Heparan Sulfate Proteoglycans, Research Article
extracellular matrix, Fluorescent Antibody Technique, Gene Expression, Microbiology, Bacterial Adhesion, Cornea, Mice, host-pathogen interactions, Animals, Keratitis, Mice, Knockout, syndecans, Immunohistochemistry, QR1-502, Extracellular Matrix, Fibronectins, Disease Models, Animal, keratitis, Streptococcus pneumoniae, Gain of Function Mutation, Host-Pathogen Interactions, proteoglycans, Syndecan-1, Heparan Sulfate Proteoglycans, Research Article
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