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Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis

descriptionPublicationkeyboard_double_arrow_right Article 15 Jun 2018 English Publisher:American Society for MicrobiologyJournal:Journal of Virology, volume 92 (issn: 0022-538X, eissn: 1098-5514,

Authors: Siew-Wai Fong; Siew-Wai Fong; R. Manjunatha Kini; Lisa F. P. Ng; Lisa F. P. Ng;

doi: 10.1128/jvi.01004-17

pmid: 29593049

pmc: PMC5974479

Mosquito Saliva Reshapes Alphavirus Infection and Immunopathogenesis

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Abstract

ABSTRACT Alphaviruses are transmitted to humans via bites of infected mosquitoes. Although alphaviruses have caused a wide range of outbreaks and crippling disease, the availability of licensed vaccines or antiviral therapies remains limited. Mosquito vectors such as Aedes and Culex are the main culprits in the transmission of alphaviruses. This review explores how mosquito saliva may promote alphavirus infection. Identifying the roles of mosquito-derived factors in alphavirus pathogenesis will generate novel tools to circumvent and control mosquito-borne alphavirus infections in humans.

Related Organizations

University of Liverpool
United Kingdom
Agency for Science, Technology and Research
Singapore
National University of Singapore
Singapore

Keywords

Immunosuppression Therapy, Alphavirus Infections, Alphavirus, Adaptive Immunity, Immunity, Innate, Culex, Aedes, Animals, Humans, Saliva, Skin

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	23
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%