Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains
Copyright policy )Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains
There is strong evidence that coronaviruses and other large nidoviruses evolved a number of unique enzymatic activities, including an additional RdRp-associated NiRAN domain, that are conserved in nidoviruses but not in most other RNA viruses. Previous studies of the NiRAN domain mainly focused on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suggested different functions for this domain, such as NMPylation/RNAylation of nsp9, RNA guanylyltransferase activities involved in canonical and/or unconventional RNA capping pathways, and other functions.
- Justus Liebig University Giessen Germany
- Phillips University United States
Nucleotides, SARS-CoV-2, Coronaviridae, Viral Nonstructural Proteins, RNA-Dependent RNA Polymerase, Protein Structure, Secondary, Genome Replication and Regulation of Viral Gene Expression, Viral Proteins, Protein Domains, Humans, RNA, Viral, Vero Cells, Conserved Sequence
Nucleotides, SARS-CoV-2, Coronaviridae, Viral Nonstructural Proteins, RNA-Dependent RNA Polymerase, Protein Structure, Secondary, Genome Replication and Regulation of Viral Gene Expression, Viral Proteins, Protein Domains, Humans, RNA, Viral, Vero Cells, Conserved Sequence
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