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Nitric Oxide Inhibition of Rickettsia rickettsii

descriptionPublicationkeyboard_double_arrow_right Article 16 Nov 2021 English Publisher:American Society for MicrobiologyJournal:Infection and Immunity, volume 89 (issn: 0019-9567, eissn: 1098-5522,

Authors: Liam F. Fitzsimmons; Tina R. Clark; Ted Hackstadt;

doi: 10.1128/iai.00371-21

pmid: 34491789

pmc: PMC8594597

Nitric Oxide Inhibition of Rickettsia rickettsii

- Summary
- Subjects
- Metrics

Abstract

Rickettsia rickettsii , the causative agent of Rocky Mountain spotted fever, is an enzootic, obligate, intracellular bacterial pathogen. Nitric oxide (NO) synthesized by the inducible NO synthase (iNOS) is a potent antimicrobial component of innate immunity and has been implicated in the control of virulent Rickettsia spp. in diverse cell types.

Related Organizations

National Institute of Health
Pakistan
National Institute of Allergy and Infectious Diseases
United States
National Institutes of Health
United States
National Institute of Health
United States
National Institute of Health (NIH/NICHD)
United States

Keywords

Macrophages, Host-Pathogen Interactions, Rickettsia rickettsii, Nitric Oxide Synthase Type II, Energy Metabolism, Nitric Oxide, Rocky Mountain Spotted Fever, Immunity, Innate

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average