Molecular Epidemiology of Extraintestinal PathogenicEscherichia coli
Copyright policy )Molecular Epidemiology of Extraintestinal PathogenicEscherichia coli
Extraintestinal pathogenicEscherichia coli(ExPEC), the specializedE. colistrains that possess the ability to overcome or subvert host defenses and cause extraintestinal disease, are important pathogens in humans and certain animals. Molecular epidemiological analysis has led to an appreciation of ExPEC as being distinct from otherE. coli(including intestinal pathogenic and commensal variants) and has offered insights into the ecology, evolution, reservoirs, transmission pathways, host-pathogen interactions, and pathogenetic mechanisms of ExPEC. Molecular epidemiological analysis also provides an essential complement to experimental assessment of virulence mechanisms. This chapter first reviews the basic conceptual and methodological underpinnings of the molecular epidemiological approach and then summarizes the main aspects of ExPEC that have been investigated using this approach.
- State University of New York at Potsdam United States
- University of Minnesota United States
- VA Western New York Healthcare System United States
- University at Buffalo, State University of New York United States
- University of Minnesota Morris United States
Molecular Epidemiology, Genotype, Virulence, Whole Genome Sequencing, Extraintestinal Pathogenic Escherichia coli, Virulence Factors, Mice, Animals, Humans, Escherichia coli Infections, Genome, Bacterial, Phylogeny
Molecular Epidemiology, Genotype, Virulence, Whole Genome Sequencing, Extraintestinal Pathogenic Escherichia coli, Virulence Factors, Mice, Animals, Humans, Escherichia coli Infections, Genome, Bacterial, Phylogeny
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