In Vitro Susceptibility of Varicella Zoster Virus to Adenine Arabinoside and Hypoxanthine Arabinoside
Copyright policy )In Vitro Susceptibility of Varicella Zoster Virus to Adenine Arabinoside and Hypoxanthine Arabinoside
The in vitro susceptibility of varicella zoster (VZ) isolates to adenine arabinoside (ara-A) and hypoxanthine arabinoside (ara-Hx) was determined in human skin fibroblasts. Using a system in which deamination was inhibited, and using a modified plaque reduction method, the antiviral activities of ara-A and ara-Hx were separated. The plaque inhibitory concentration of ara-A for all VZ isolates tested was 1 to 2 μg/ml and 80 to 100 μg/ml for ara-Hx. A comparison of antiviral activity based upon total plaque suppression gave a rate of 40 to 50:1, in favor of ara-A.
- University of California, San Diego United States
Herpesvirus 3, Human, Cytopathogenic Effect, Viral, Culture Techniques, Purine Nucleosides, Viral Plaque Assay, Vidarabine
Herpesvirus 3, Human, Cytopathogenic Effect, Viral, Culture Techniques, Purine Nucleosides, Viral Plaque Assay, Vidarabine
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