Preparation of Succinyl Neocarzinostatin

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 1974 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 5, pages 354-355 (issn: 0066-4804, eissn: 1098-6596,

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Authors: H, Maeda;

doi: 10.1128/aac.5.3.354

pmid: 4840443

pmc: PMC428972

Preparation of Succinyl Neocarzinostatin

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Abstract

All amino groups in a proteinous antitumor antibiotic, neocarzinostatin, were reacted with succinic anhydride yielding bis- N -succinyl neocarzinostatin which retained biological activity in vitro against human cell lines and a bacterium. Amino groups in neocarzinostatin do not appear to play an important role in the activity.

Related Organizations

Kumamoto University
Japan

Keywords

Antibiotics, Antineoplastic, Sarcina, Proteins, Succinates

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