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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
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https://dx.doi.org/10.1128/aac...
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Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2002 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 46, pages 259-261 (issn: 0066-4804, eissn: 1098-6596, Copyright policy )
Authors: Chiranjib, Pal; Mousumi, Raha; Anirban, Basu; Keshab Chandra, Roy; Anasuya, Gupta; Monidipa, Ghosh; Niranjan Prasad, Sahu; +3 Authors

doi: 10.1128/aac.46.1.259-261.2002

pmid: 11751149

pmc: PMC126984

Combination Therapy with Indolylquinoline Derivative and Sodium Antimony Gluconate Cures Established Visceral Leishmaniasis in Hamsters

Abstract

ABSTRACT 2-(2″-Dichloroacetamidobenzyl)-3-(3′-indolylquinoline), designated indolylquinoline derivative A, reduced the splenic and the liver parasite burdens by >93.0% in Leishmania donovani -infected hamsters, whereas sodium antimony gluconate (SAG) reduced the burdens approximately 80.0%. Complete clearance of parasitemia from the livers and spleens was noticed when infected animals received indolylquinoline derivative A plus SAG, suggesting that indolylquinoline derivative A has potential as a new agent for sole or conjunctive therapy for leishmaniasis.

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Keywords

Disease Models, Animal, Indoles, Treatment Outcome, Antimony Sodium Gluconate, Cricetinae, Antiprotozoal Agents, Quinolines, Animals, Leishmaniasis, Visceral, Drug Therapy, Combination

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Average
bronze
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