The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection
Copyright policy )The Ovine Cathelicidin SMAP29 Kills Ovine Respiratory Pathogens In Vitro and in an Ovine Model of Pulmonary Infection
ABSTRACT Cathelicidins are antimicrobial peptides from sheep (SMAP29 and SMAP34), rabbits (CAP11 and CAP18), rodents (CRAMP), and humans (FALL39, LL37, and h/CAP18). In a broth microdilution assay against nine ovine pathogens, SMAP29, SMAP34, mouse CRAMP, CAP18, CAP18 31 , CAP18 28 , CAP18 22 , and CAP18 21a were the most active, with MICs as low as 0.6 μg/ml. Other cathelicidins were less active. In lambs with pneumonia, 0.5 mg of SMAP29 reduced the concentration of bacteria in both bronchoalveolar lavage fluid and consolidated pulmonary tissues. Hence, the antimicrobial activity of SMAP29 suggests that it has applications in the treatment of respiratory tract infections.
- National Animal Disease Center United States
- University of Iowa United States
- Agricultural Research Service United States
- Iowa State University United States
570, Sheep, Proteins, Sheep Diseases, Blood Proteins, Pediatrics, Veterinary Pathology and Pathobiology, Anti-Bacterial Agents, Cathelicidins, Pseudomonas aeruginosa, Animals, Lung, Respiratory Tract Infections, Antimicrobial Cationic Peptides
570, Sheep, Proteins, Sheep Diseases, Blood Proteins, Pediatrics, Veterinary Pathology and Pathobiology, Anti-Bacterial Agents, Cathelicidins, Pseudomonas aeruginosa, Animals, Lung, Respiratory Tract Infections, Antimicrobial Cationic Peptides
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).74 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!