Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004)

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1997 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 41, pages 2,019-2,022 (issn: 0066-4804, eissn: 1098-6596,

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Authors: L M, Ednie; M R, Jacobs; P C, Appelbaum;

doi: 10.1128/aac.41.9.2019

pmid: 9303406

pmc: PMC164057

Comparative antianaerobic activities of the ketolides HMR 3647 (RU 66647) and HMR 3004 (RU 64004)

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Abstract

HMR 3647 (RU 66647) and HMR 3004 (RU 64004), two ketolides, had MICs at which 50% of the strains are inhibited (MIC50s) of 0.06 to 0.125 microg/ml and MIC90s of 16.0 microg/ml against 352 anaerobes. MIC50s and MIC90s of erythromycin, azithromycin, clarithromycin, and roxithromycin were 0.5 to 2.0 microg/ml and 32.0 to >64.0 microg/ml, respectively. HMR 3647 and HMR 3004 were more active against non-Bacteroides fragilis-group anaerobes (other than Fusobacterium mortiferum, Fusobacterium varium, and Clostridium difficile).

Related Organizations

Penn State Milton S. Hershey Medical Center
United States

Keywords

Ketolides, Roxithromycin, Microbial Sensitivity Tests, Azithromycin, Carbon Dioxide, Hydrogen-Ion Concentration, Anti-Bacterial Agents, Erythromycin, Bacteria, Anaerobic, Clarithromycin, Macrolides

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