Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant
Copyright policy )Emergence of an inhibitor-resistant beta-lactamase (SHV-10) derived from an SHV-5 variant
An inhibitor-resistant beta-lactamase (SHV-10), derived from an SHV-5 variant (SHV-9), was found in an Escherichia coli clinical isolate. In SHV-10, Ser-130 was replaced by Gly. The enzyme partially retained its ability to hydrolyze penicillins, but its activity against cephalosporins was drastically reduced. A Ser-130-->Gly mutant of the prototype SHV-5, obtained by site-directed mutagenesis, had properties similar to those of SHV-10.
- Institut Pasteur France
- Pasteur Hellenic Institute Greece
Escherichia coli, Humans, Drug Resistance, Microbial, beta-Lactamase Inhibitors, beta-Lactams, Escherichia coli Infections, beta-Lactamases, Anti-Bacterial Agents
Escherichia coli, Humans, Drug Resistance, Microbial, beta-Lactamase Inhibitors, beta-Lactams, Escherichia coli Infections, beta-Lactamases, Anti-Bacterial Agents
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