Antiprotozoal Activity of Rubratoxin B

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1973 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 4, pages 80-84 (issn: 0066-4804, eissn: 1098-6596,

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Authors: A W, Hayes;

doi: 10.1128/aac.4.2.80

pmid: 4208507

pmc: PMC444510

Antiprotozoal Activity of Rubratoxin B

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Abstract

Growth of Tetrahymena pyriformis HSM was inhibited by a concentration of 25 μg of rubratoxin B per ml of growth medium. The inhibitory effect of aflatoxin B 1 -rubratoxin B mixtures on growth of T. pyriformis was induced by rubratoxin B only. Total cellular deoxyribonucleic acid increased in the presence of 5 μg of rubratoxin B per ml of growth medium, whereas higher concentrations (25 μg/ml of growth medium) were required before a decrease in total protein was observed.

Related Organizations

Alabama Agricultural and Mechanical University
United States
University of Alabama - USA
United States

Keywords

Tetrahymena pyriformis, Antiprotozoal Agents, Penicillium, Animals, Proteins, DNA, Mycotoxins

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