Inactivation of rifampin by Nocardia brasiliensis

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 1993 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 37, pages 1,313-1,317 (issn: 0066-4804, eissn: 1098-6596,

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Authors: K, Yazawa; Y, Mikami; A, Maeda; M, Akao; N, Morisaki; S, Iwasaki;

doi: 10.1128/aac.37.6.1313

pmid: 8328779

pmc: PMC187958

Inactivation of rifampin by Nocardia brasiliensis

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Abstract

Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.

Related Organizations

Chiba University
Japan

Keywords

Glycosylation, Magnetic Resonance Spectroscopy, Inactivation, Metabolic, Microbial Sensitivity Tests, Rifampin, Mass Spectrometry, Nocardia

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