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In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin and pristinamycin

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1989 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 33, pages 2,146-2,148 (issn: 0066-4804, eissn: 1098-6596,

Authors: M Drancourt; D Raoult;

doi: 10.1128/aac.33.12.2146

pmid: 2515795

pmc: PMC172839

In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin and pristinamycin

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Abstract

In vitro susceptibilities of Rickettsia rickettsii and Rickettsia conorii to roxithromycin, pristinamycin, and the pristinamycin compounds, P1 and P2, were determined by a dye uptake assay and a plaque assay. The MICs were 1 microgram/ml for roxithromycin, 2 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 2 micrograms/ml for P2. Compounds P1 and P2 did not share synergetic activity. The toxicity of each compound was determined by a dye uptake assay. Toxic concentrations were 128 micrograms/ml for roxithromycin, 32 micrograms/ml for pristinamycin, greater than 256 micrograms/ml for P1, and 32 micrograms/ml for P2. Roxithromycin and pristinamycin could be useful in the treatment of Rocky Mountain spotted fever and Mediterranean spotted fever.

Keywords

Roxithromycin, Rickettsia rickettsii, Animals, Microbial Sensitivity Tests, Rickettsia, Peptides, Cyclic, Vero Cells, Virginiamycin, Anti-Bacterial Agents

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