beta-Lactamases and beta-lactam resistance in Escherichia coli

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1985 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 28, pages 703-705 (issn: 0066-4804, eissn: 1098-6596,

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Authors: G A, Jacoby; L, Sutton;

doi: 10.1128/aac.28.5.703

pmid: 3911882

pmc: PMC176364

beta-Lactamases and beta-lactam resistance in Escherichia coli

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Abstract

Escherichia coli strains determining 17 different plasmid-determined beta-lactamases were tested for resistance to new broad-spectrum beta-lactam antibiotics. Several beta-lactamases demonstrated enhanced resistance to cefamandole but only low-level resistance to other agents. High production of cloned E. coli chromosomal beta-lactamase, however, provided resistance to cefamandole, cefoxitin, cefotaxime, ceftazidime, and aztreonam but not to BMY-28142 or imipenem.

Related Organizations

Massachusetts General Hospital
United States

Keywords

Escherichia coli, Drug Resistance, Microbial, Microbial Sensitivity Tests, beta-Lactams, beta-Lactamases, Anti-Bacterial Agents

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