Elimination of plasmids by new 4-quinolones

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 1985 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 28, pages 700-702 (issn: 0066-4804, eissn: 1098-6596,

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Authors: J, Weisser; B, Wiedemann;

doi: 10.1128/aac.28.5.700

pmid: 3911881

pmc: PMC176363

Elimination of plasmids by new 4-quinolones

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Abstract

Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.

Keywords

Escherichia coli, Quinolines, Drug Resistance, Microbial, Microbial Sensitivity Tests, Plasmids

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