In vitro activity of ciprofloxacin against aerobic gram-negative bacteria

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1984 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 26, pages 597-598 (issn: 0066-4804, eissn: 1098-6596,

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Authors: J E, Rudin; C W, Norden; E M, Shinners;

doi: 10.1128/aac.26.4.597

pmid: 6517550

pmc: PMC179973

In vitro activity of ciprofloxacin against aerobic gram-negative bacteria

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Abstract

For 177 gram-negative isolates, the MICs for ciprofloxacin ranged from 0.02 microgram/ml (Escherichia coli) to 0.31 microgram/ml (Pseudomonas aeruginosa). In time-kill curves, ciprofloxacin at 8 X the MIC almost completely killed 10(6) CFU of P. aeruginosa by 24 h. Ciprofloxacin at 4 X the MIC allowed bacterial regrowth by 24 h, with development of partial resistance to ciprofloxacin.

Keywords

Bacteria, Aerobic, Ciprofloxacin, Quinolines, Microbial Sensitivity Tests, Anti-Bacterial Agents

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