In vitro activity of N-formimidoyl thienamycin (MK0787)

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1980 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 18, pages 642-644 (issn: 0066-4804, eissn: 1098-6596,

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Authors: F P, Tally; N V, Jacobus; S L, Gorbach;

doi: 10.1128/aac.18.4.642

pmid: 6934708

pmc: PMC284063

In vitro activity of N-formimidoyl thienamycin (MK0787)

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Abstract

The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.

Keywords

Imipenem, Bacteria, Lactams, Microbial Sensitivity Tests, Anti-Bacterial Agents

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