Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States
Copyright policy )Chromosomal Mutations Responsible for Fluoroquinolone Resistance in Ureaplasma Species in the United States
ABSTRACT We sequenced the full lengths of the gyrA , gyrB , parC , and parE genes in 13 fluoroquinolone-resistant Ureaplasma isolates (levofloxacin MICs, 4 to 32 μg/ml) and 10 susceptible isolates (MICs ≤ 2 μg/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.
- University of Alabama at Birmingham United States
- J. Craig Venter Institute United States
- Alabama Agricultural and Mechanical University United States
DNA Topoisomerase IV, Ofloxacin, Ureaplasma Infections, Levofloxacin, Microbial Sensitivity Tests, Sequence Analysis, DNA, Chromosomes, Bacterial, Ureaplasma, United States, Anti-Bacterial Agents, Isoenzymes, DNA Gyrase, Drug Resistance, Bacterial, Mutation, Humans, Longitudinal Studies
DNA Topoisomerase IV, Ofloxacin, Ureaplasma Infections, Levofloxacin, Microbial Sensitivity Tests, Sequence Analysis, DNA, Chromosomes, Bacterial, Ureaplasma, United States, Anti-Bacterial Agents, Isoenzymes, DNA Gyrase, Drug Resistance, Bacterial, Mutation, Humans, Longitudinal Studies
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