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Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations

descriptionPublicationkeyboard_double_arrow_right Article 18 Mar 2021 United States English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 65 (issn: 0066-4804, eissn: 1098-6596,

Authors: Nathan P. Wiederhold; Ilan S. Schwartz; Thomas F. Patterson; George R. Thompson;

doi: 10.1128/aac.02353-20

pmid: 33468480

pmc: PMC8097436

Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations

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Abstract

We analyzed the relationship between itraconazole (ITZ) and hydroxy-itraconazole (OH-ITZ) levels in 1,223 human samples. Overall, there was a statistically significant correlation between ITZ and OH-ITZ levels (Pearson’s r , 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96).

Country

United States

Related Organizations

South Texas Veterans Health Care System
United States
The University of Texas Health Science Center at San Antonio
United States
University of California, Davis
United States
University of Alberta
Canada
University of California System
United States

Keywords

Antifungal Agents, Neurosciences, Pharmacology and Pharmaceutical Sciences, hydroxy-itraconazole, Microbiology, itraconazole, TDM, therapeutic-drug monitoring, bloodstream concentrations, bioassay, Medical Microbiology, antifungal efficacy, Humans, Itraconazole

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