Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C
Copyright policy )Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C
ABSTRACT Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.
- Centre national de la recherche scientifique France
- Radboud University Nijmegen Netherlands
- KU Leuven Belgium
- Aix-Marseille University France
- Radboud University Nijmegen Medical Centre Netherlands
MECHANISM, GUANIDINE, Coronacrisis-Taverne, 3214 Pharmacology and pharmaceutical sciences, Viral Nonstructural Proteins, Microbiology, POLYPEPTIDE, REGION, 1108 Medical Microbiology, Fluoxetine, REVEALS, Pharmacology & Pharmacy, POLIOVIRUS 2C, Enterovirus D, Human, Science & Technology, 3207 Medical microbiology, Enterovirus B, Human, 3107 Microbiology, CELLS, RNA, MEMBRANE-BINDING, ATPASE ACTIVITY, 1115 Pharmacology and Pharmaceutical Sciences, Carrier Proteins, N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity, Life Sciences & Biomedicine, N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity, Selective Serotonin Reuptake Inhibitors, 0605 Microbiology
MECHANISM, GUANIDINE, Coronacrisis-Taverne, 3214 Pharmacology and pharmaceutical sciences, Viral Nonstructural Proteins, Microbiology, POLYPEPTIDE, REGION, 1108 Medical Microbiology, Fluoxetine, REVEALS, Pharmacology & Pharmacy, POLIOVIRUS 2C, Enterovirus D, Human, Science & Technology, 3207 Medical microbiology, Enterovirus B, Human, 3107 Microbiology, CELLS, RNA, MEMBRANE-BINDING, ATPASE ACTIVITY, 1115 Pharmacology and Pharmaceutical Sciences, Carrier Proteins, N4i 1: Pathogenesis and modulation of inflammation NCMLS 1: Infection and autoimmunity, Life Sciences & Biomedicine, N4i 3: Poverty-related infectious diseases NCMLS 1: Infection and autoimmunity, Selective Serotonin Reuptake Inhibitors, 0605 Microbiology
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