Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation
Copyright policy )Isoniazid Bactericidal Activity Involves Electron Transport Chain Perturbation
Accumulating evidence suggests that the bactericidal activity of some antibiotics may not be directly initiated by target inhibition. The activity of isoniazid (INH), a key first-line bactericidal antituberculosis drug currently known to inhibit mycolic acid synthesis, becomes extremely poor under stress conditions, such as hypoxia and starvation.
- Sciensano (Belgium) Belgium
- Université Libre de Bruxelles Belgium
- Vrije Universiteit Amsterdam Netherlands
- University of Mons Belgium
isoniazid, Bedaquiline, Pyridines, Antitubercular Agents, Membrane Potentials, Persistence, Electron Transport, Electron Transport Complex IV, Adenosine Triphosphate, Oxygen Consumption, SDG 3 - Good Health and Well-being, Piperidines, Immunologie, Isoniazid, bedaquiline, Diarylquinolines, electron transport chain, Imidazoles, Biologie moléculaire, persistence, Mycobacterium tuberculosis, Cytochrome b Group, Mycobacterium bovis, Electron Transport Chain Complex Proteins, Electron transport chain, Biologie cellulaire, Q203, Microbiologie et protistologie [bacteriol.virolog.mycolog.], Oxidation-Reduction
isoniazid, Bedaquiline, Pyridines, Antitubercular Agents, Membrane Potentials, Persistence, Electron Transport, Electron Transport Complex IV, Adenosine Triphosphate, Oxygen Consumption, SDG 3 - Good Health and Well-being, Piperidines, Immunologie, Isoniazid, bedaquiline, Diarylquinolines, electron transport chain, Imidazoles, Biologie moléculaire, persistence, Mycobacterium tuberculosis, Cytochrome b Group, Mycobacterium bovis, Electron Transport Chain Complex Proteins, Electron transport chain, Biologie cellulaire, Q203, Microbiologie et protistologie [bacteriol.virolog.mycolog.], Oxidation-Reduction
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