Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2019 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 63 (issn: 0066-4804, eissn: 1098-6596,

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Authors: Benni, Vargas; Nicholas S, Giacobbi; Anwesha, Sanyal; Narasimhan J, Venkatachari; Feng, Han; Phalguni, Gupta; Nicolas, Sluis-Cremer;

doi: 10.1128/aac.01744-18

pmid: 30455231

pmc: PMC6355603

Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency

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Abstract

Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell permeable kinase inhibitors, which target a wide range of signaling pathways, to identify inhibitors of HIV-1 latency reversal.

Related Organizations

University of Pittsburgh
United States

Keywords

CD4-Positive T-Lymphocytes, Anti-HIV Agents, HIV Infections, Cell Line, Benzamides, HIV-1, Humans, Pyrazoles, Pyrroles, Virus Activation, Signal Transduction

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