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Pharmacokinetics and Tissue Distribution of Anidulafungin in Rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2008 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 52, pages 2,673-2,676 (issn: 0066-4804, eissn: 1098-6596,

Authors: Martin Stogniew; Bharat Damle; James A. Dowell;

doi: 10.1128/aac.01596-07

pmid: 18443124

pmc: PMC2443878

Pharmacokinetics and Tissue Distribution of Anidulafungin in Rats

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Abstract

ABSTRACT This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.

Related Organizations

Pfizer (United States)
United States

Keywords

Male, Antifungal Agents, Candidiasis, Anidulafungin, Kidney, Rats, Inbred F344, Rats, Echinocandins, Liver, Animals, Autoradiography, Humans, Tissue Distribution, Carbon Radioisotopes, Infusions, Intravenous, Lung, Spleen

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	50
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%