In Vitro Activity of Tigecycline against Multidrug-Resistant  Acinetobacter baumannii  and Selection of Tigecycline-Amikacin Synergy

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2008 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 52, pages 2,940-2,942 (issn: 0066-4804, eissn: 1098-6596,

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Authors: Ellen S, Moland; David W, Craft; Seong-geun, Hong; Soo-young, Kim; Lucas, Hachmeister; Shimon D, Sayed; Kenneth S, Thomson;

doi: 10.1128/aac.01581-07

pmid: 18519722

pmc: PMC2493109

In Vitro Activity of Tigecycline against Multidrug-Resistant Acinetobacter baumannii and Selection of Tigecycline-Amikacin Synergy

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Abstract

ABSTRACT Polymyxin B, minocycline, and tigecycline were the most potent of 10 antibiotics against 170 isolates of multidrug-resistant Acinetobacter baumannii . In time-kill studies, the exposure of a highly tigecycline-resistant isolate to tigecycline resulted in enhanced susceptibility to amikacin and synergistic bactericidal activities of the two drugs.

Related Organizations

Creighton University School of Medicine
United States
Walter Reed Army Medical Center
United States
Creighton University
United States

Keywords

Acinetobacter baumannii, Drug Resistance, Multiple, Bacterial, Drug Synergism, Minocycline, Microbial Sensitivity Tests, Amikacin, Tigecycline

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