Reduced  Candida glabrata  Susceptibility Secondary to an  FKS1  Mutation Developed during Candidemia Treatment

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2008 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 52, pages 2,263-2,265 (issn: 0066-4804, eissn: 1098-6596,

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Authors: John D, Cleary; Guillermo, Garcia-Effron; Stanley W, Chapman; David S, Perlin;

doi: 10.1128/aac.01568-07

pmid: 18378714

pmc: PMC2415792

Reduced Candida glabrata Susceptibility Secondary to an FKS1 Mutation Developed during Candidemia Treatment

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Abstract

ABSTRACT We describe a case of recurring Candida glabrata infection in a 68-year-old African-American female on caspofungin therapy. The initial isolate was susceptible, but isolates recovered during following relapses were not. All isolates were clonal, and high-MIC strains contained a mutation in the highly conserved hot spot 1 region of Fks1p.

Related Organizations

Rutgers, The State University of New Jersey
United States
University of Mississippi
United States
Rutgers New Jersey Medical School
United States

Keywords

Antifungal Agents, Candidiasis, Membrane Proteins, Candida glabrata, Microbial Sensitivity Tests, Fungal Proteins, Echinocandins, Lipopeptides, Fatal Outcome, Caspofungin, Drug Resistance, Fungal, Glucosyltransferases, Mutation, Humans, Female, Fungemia, Aged

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