In Vitro Antimycobacterial Activities of Capuramycin Analogues

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2008 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 52, pages 719-721 (issn: 0066-4804, eissn: 1098-6596,

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Authors: Venkata M, Reddy; Leo, Einck; Carol A, Nacy;

doi: 10.1128/aac.01469-07

pmid: 18070956

pmc: PMC2224724

In Vitro Antimycobacterial Activities of Capuramycin Analogues

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Abstract

ABSTRACT Translocase I inhibitor compounds derived from capuramycin demonstrated rapid bactericidal activity against several different mycobacterial species. SQ641 was the most active of the compounds, with a MIC of 0.12 to 8 μg/ml, a postantibiotic effect of 55 h, and interesting synergistic effects with other antitubercular drugs.

Keywords

Aminoglycosides, Antitubercular Agents, Humans, Nucleosides, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Mycobacterium avium Complex, Mycobacterium

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