Temporal Appearance of Plasmid-Mediated Quinolone Resistance Genes

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2009 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 53, pages 1,665-1,666 (issn: 0066-4804, eissn: 1098-6596,

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Authors: George A, Jacoby; Nancy, Gacharna; Todd A, Black; George H, Miller; David C, Hooper;

doi: 10.1128/aac.01447-08

pmid: 19164145

pmc: PMC2663075

Temporal Appearance of Plasmid-Mediated Quinolone Resistance Genes

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Abstract

ABSTRACT One hundred fifty AAC(6′)-Ib-positive gram-negative isolates collected between 1981 and 1991 were examined by PCR for the presence of the aac(6 ′ )-Ib-cr variant and other plasmid-mediated quinolone resistance (PMQR) genes. None had the aac(6 ′ )-Ib-cr variant, qnrA , qnrS , qnrC , or qepA , but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes.

Related Organizations

Harvard University
United States
Schering-Plough
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Massachusetts General Hospital
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Lahey Medical Center
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Keywords

Acetyltransferases, Escherichia coli Proteins, Drug Resistance, Bacterial, Quinolines, Polymerase Chain Reaction, Anti-Bacterial Agents, Plasmids

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