Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates
Copyright policy )Most-Probable-Number-Based Minimum Duration of Killing Assay for Determining the Spectrum of Rifampicin Susceptibility in Clinical Mycobacterium tuberculosis Isolates
Accurate antibiotic susceptibility testing is essential for successful tuberculosis treatment. Recent studies have highlighted the limitations of MIC-based phenotypic susceptibility methods in detecting other aspects of antibiotic susceptibilities in bacteria. Duration and peak of antibiotic exposure, at or above the MIC required for killing the bacterial population, has emerged as another important factor for determining antibiotic susceptibility. This is broadly defined as antibiotic tolerance.
- University of Oxford United Kingdom
- University of California System United States
- University of Oxford, Centre for Tropical Medicine and Global Health, UK Centre United Kingdom
- Vietnam National University, Ho Chi Minh City Viet Nam
- Beijing Advanced Sciences and Innovation Center China (People's Republic of)
Epidemiology, Population, Antitubercular Agents, FOS: Basic medicine, Microbial Sensitivity Tests, FOS: Health sciences, Microbiology, Diagnosis, Treatment, and Epidemiology of Nontuberculous Mycobacterial Diseases, Global Challenge of Antibiotic Resistance in Bacteria, Antibiotics, Biochemistry, Genetics and Molecular Biology, Drug Resistance, Bacterial, Health Sciences, Pathology, Tuberculosis, Biology, Rifampicin, Life Sciences, DNA-Directed RNA Polymerases, Mycobacterium tuberculosis, Infectious Diseases, Environmental health, Susceptibility, Antibiotic Resistance, FOS: Biological sciences, Antibacterial agent, Medicine, Molecular Medicine, Rifampin
Epidemiology, Population, Antitubercular Agents, FOS: Basic medicine, Microbial Sensitivity Tests, FOS: Health sciences, Microbiology, Diagnosis, Treatment, and Epidemiology of Nontuberculous Mycobacterial Diseases, Global Challenge of Antibiotic Resistance in Bacteria, Antibiotics, Biochemistry, Genetics and Molecular Biology, Drug Resistance, Bacterial, Health Sciences, Pathology, Tuberculosis, Biology, Rifampicin, Life Sciences, DNA-Directed RNA Polymerases, Mycobacterium tuberculosis, Infectious Diseases, Environmental health, Susceptibility, Antibiotic Resistance, FOS: Biological sciences, Antibacterial agent, Medicine, Molecular Medicine, Rifampin
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