KPC-53, a KPC-3 Variant of Clinical Origin Associated with Reduced Susceptibility to Ceftazidime-Avibactam
Copyright policy )KPC-53, a KPC-3 Variant of Clinical Origin Associated with Reduced Susceptibility to Ceftazidime-Avibactam
This study reports on the characterization of a Klebsiella pneumoniae clinical isolate showing high-level resistance to ceftazidime-avibactam associated with the production of KPC-53, a KPC-3 variant exhibiting a Leu167Glu168 duplication in the Ω-loop and a loss of carbapenemase activity. Whole-genome sequencing (WGS) revealed the presence of two copies of bla KPC-53 , located on a pKpQIL-like plasmid and on a plasmid prophage of the Siphoviridae family, respectively.
- University of Florence Italy
- University of Genoa Italy
- Alessandro Manzoni Hospital Italy
Carbapenem-resistant Enterobacterales; CZA resistance; Mutant KPC carbapenemase; Phagemid; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Drug Resistance, Multiple, Bacterial; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; beta-Lactamases; Klebsiella Infections, Microbial Sensitivity Tests, Ceftazidime, beta-Lactamases, Anti-Bacterial Agents, Klebsiella Infections, Drug Combinations, Klebsiella pneumoniae, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Humans, Carbapenem-resistant Enterobacterales; CZA resistance; Mutant KPC carbapenemase; Phagemid, Azabicyclo Compounds
Carbapenem-resistant Enterobacterales; CZA resistance; Mutant KPC carbapenemase; Phagemid; Anti-Bacterial Agents; Azabicyclo Compounds; Bacterial Proteins; Ceftazidime; Drug Combinations; Drug Resistance, Multiple, Bacterial; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; beta-Lactamases; Klebsiella Infections, Microbial Sensitivity Tests, Ceftazidime, beta-Lactamases, Anti-Bacterial Agents, Klebsiella Infections, Drug Combinations, Klebsiella pneumoniae, Bacterial Proteins, Drug Resistance, Multiple, Bacterial, Humans, Carbapenem-resistant Enterobacterales; CZA resistance; Mutant KPC carbapenemase; Phagemid, Azabicyclo Compounds
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).24 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!