Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility
Copyright policy )Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility
Multiple Erg11 amino acid substitutions were identified in clinical isolates of Candida auris originating from India and Colombia. Elevated azole MICs were detected in Saccharomyces cerevisiae upon heterologous expression of C. auris ERG11 alleles that encoded for Y132F or K143R substitutions; however, expression of alleles encoding I466M, Y501H, or other clade-defined amino acid differences yielded susceptible MICs.
- Rutgers, The State University of New Jersey United States
- Rutgers New Jersey Medical School United States
- University of Delhi India
- Rutgers Biomedical and Health Sciences United States
- Public Health Institute United States
Azoles, Diagnosis and Management of Fungal Infections, Fungi imperfecti, Antifungal Agents, Epidemiology, Microbial Sensitivity Tests, Saccharomyces cerevisiae, FOS: Health sciences, Antifungal, Microbiology, Gene, Epidemiology and Management of Fungal Infections, Cytochrome P-450 Enzyme System, Mechanisms of Resistance, Drug Resistance, Fungal, Health Sciences, Genetics, Biology, Candida, Allele, Heterologous, Mutant, Genetic Analysis, Candida auris, Infectious Diseases, FOS: Biological sciences, Methicillin-Resistant Staphylococcus aureus Infections, Mutation, Medicine, Azole
Azoles, Diagnosis and Management of Fungal Infections, Fungi imperfecti, Antifungal Agents, Epidemiology, Microbial Sensitivity Tests, Saccharomyces cerevisiae, FOS: Health sciences, Antifungal, Microbiology, Gene, Epidemiology and Management of Fungal Infections, Cytochrome P-450 Enzyme System, Mechanisms of Resistance, Drug Resistance, Fungal, Health Sciences, Genetics, Biology, Candida, Allele, Heterologous, Mutant, Genetic Analysis, Candida auris, Infectious Diseases, FOS: Biological sciences, Methicillin-Resistant Staphylococcus aureus Infections, Mutation, Medicine, Azole
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