In Vitro Susceptibility of Field Isolates of  Leishmania donovani  to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2009 English Publisher:American Society for MicrobiologyJournal:Antimicrobial Agents and Chemotherapy, volume 53, pages 835-838 (issn: 0066-4804, eissn: 1098-6596,

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Authors: Dhiraj, Kumar; Arpita, Kulshrestha; Ruchi, Singh; Poonam, Salotra;

doi: 10.1128/aac.01233-08

pmid: 19015344

pmc: PMC2630609

In Vitro Susceptibility of Field Isolates of Leishmania donovani to Miltefosine and Amphotericin B: Correlation with Sodium Antimony Gluconate Susceptibility and Implications for Treatment in Areas of Endemicity

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Abstract

ABSTRACT Indian Leishmania donovani isolates ( n = 19) from regional zones representing various levels of antimony resistance displayed significantly ( P < 0.01) correlated results with respect to in vitro susceptibility to the antileishmanial drugs sodium antimony gluconate, amphotericin B, and Miltefosine, raising the possibility of cross-resistance mechanisms operating in the field isolates. The results of gene expression analysis of LdMT and LdRos3 were suggestive of alternate mechanisms of Miltefosine susceptibility in the isolates.

Related Organizations

Safdarjang Hospital
India
Pathologisches Institut
Germany

Keywords

Reverse Transcriptase Polymerase Chain Reaction, Phosphorylcholine, Antiprotozoal Agents, Drug Resistance, India, Antimony Sodium Gluconate, Amphotericin B, Animals, Humans, Leishmaniasis, Visceral, DNA Primers, Leishmania donovani

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