Drug Degradation Caused by mce3R Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis
Copyright policy )Drug Degradation Caused by mce3R Mutations Confers Contezolid (MRX-I) Resistance in Mycobacterium tuberculosis
Contezolid (MRX-I), a safer antibiotic of the oxazolidinone class, is a promising new antibiotic with potent activity against Mycobacterium tuberculosis (MTB) both in vitro and in vivo . To identify resistance mechanisms of contezolid in MTB, we isolated several in vitro spontaneous contezolid-resistant MTB mutants, which exhibited 16-fold increases in the MIC of contezolid compared with the parent strain but were still unexpectedly susceptible to linezolid.
- Fudan University
- Chinese Academy of Sciences China (People's Republic of)
- Hangzhou Red Cross Hospital China (People's Republic of)
- Fudan University China (People's Republic of)
- SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES China (People's Republic of)
Pyridones, Linezolid, Antitubercular Agents, Mycobacterium tuberculosis, Microbial Sensitivity Tests, Anti-Bacterial Agents, Mixed Function Oxygenases, Flavins, Mutation, Oxazolidinones
Pyridones, Linezolid, Antitubercular Agents, Mycobacterium tuberculosis, Microbial Sensitivity Tests, Anti-Bacterial Agents, Mixed Function Oxygenases, Flavins, Mutation, Oxazolidinones
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