Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine
Copyright policy )Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine
ABSTRACT The 8-aminoquinoline tafenoquine showed significant in vitro activity against Leishmania species, including L. donovani amastigotes in macrophages, with 50% inhibitory concentrations (IC 50 s) between 0.1 and 4.0 μM for both pentavalent antimony (SbV)-sensitive and SbV-resistant strains and by oral administration in BALB/c mice, with 50% effective dose (ED 50 ) values of 1.2 to 3.5 mg/kg for 5 days. Tafenoquine was less active against intracellular Trypanosoma cruzi amastigotes, with an IC 50 of 21.9 μM.
- Spanish National Research Council Spain
- London School of Hygiene & Tropical Medicine United Kingdom
- University of London United Kingdom
- Institute of Parasitology and Biomedicine "López-Neyra" Spain
Mice, Inbred BALB C, Macrophages, Trypanosoma cruzi, Antiprotozoal Agents, Primaquine, Inhibitory Concentration 50, Mice, Aminoquinolines, Animals, Female, Leishmaniasis, Leishmania donovani
Mice, Inbred BALB C, Macrophages, Trypanosoma cruzi, Antiprotozoal Agents, Primaquine, Inhibitory Concentration 50, Mice, Aminoquinolines, Animals, Female, Leishmaniasis, Leishmania donovani
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