Molecular Basis of Class A β-Lactamase Inhibition by Relebactam
Copyright policy )Molecular Basis of Class A β-Lactamase Inhibition by Relebactam
β-Lactamase production is the major β-lactam resistance mechanism in Gram-negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase (SBL) producers, especially strains carrying the widely disseminated class A enzymes, are required. Relebactam, a diazabicyclooctane (DBO) BLI, is in phase 3 clinical trials in combination with imipenem for the treatment of infections by multidrug-resistant Enterobacteriaceae .
- University of Bristol United Kingdom
- University of Oxford United Kingdom
Models, Molecular, 570, antibiotic resistance, Genetic Vectors, 610, Gene Expression, Microbial Sensitivity Tests, diazabicyclooctane, Ceftazidime, Aztreonam, Mechanisms of Resistance, relebactam, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, avibactam, Binding Sites, Chromosomes, Bacterial, Isoenzymes, Drug Combinations, Imipenem, Klebsiella pneumoniae, Clinical Trials, Phase III as Topic, synthetic biology, /dk/atira/pure/core/keywords/biodesign_SRI; name=Bristol BioDesign Institute, serine β-lactamase inhibitors, Azabicyclo Compounds, Plasmids, Protein Binding
Models, Molecular, 570, antibiotic resistance, Genetic Vectors, 610, Gene Expression, Microbial Sensitivity Tests, diazabicyclooctane, Ceftazidime, Aztreonam, Mechanisms of Resistance, relebactam, Escherichia coli, Humans, Protein Interaction Domains and Motifs, Cloning, Molecular, avibactam, Binding Sites, Chromosomes, Bacterial, Isoenzymes, Drug Combinations, Imipenem, Klebsiella pneumoniae, Clinical Trials, Phase III as Topic, synthetic biology, /dk/atira/pure/core/keywords/biodesign_SRI; name=Bristol BioDesign Institute, serine β-lactamase inhibitors, Azabicyclo Compounds, Plasmids, Protein Binding
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