CTX-M-123, a Novel Hybrid of the CTX-M-1 and CTX-M-9 Group β-Lactamases Recovered from Escherichia coli Isolates in China
Copyright policy )CTX-M-123, a Novel Hybrid of the CTX-M-1 and CTX-M-9 Group β-Lactamases Recovered from Escherichia coli Isolates in China
ABSTRACT The chimeric bla CTX-M-123 gene was identified in two ceftazidime-resistant Escherichia coli isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14. bla CTX-M-123 is carried on related, but not identical, ∼90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1 bla CTX-M-55 gene on an additional IncI2 plasmid.
- Westmead Hospital Australia
- University of Sydney Australia
- South China Agricultural University China (People's Republic of)
- China Agricultural University China (People's Republic of)
China, Base Sequence, Escherichia coli Proteins, Molecular Sequence Data, Mutant Chimeric Proteins, Microbial Sensitivity Tests, Ceftazidime, beta-Lactamases, Bacterial Proteins, Genes, Bacterial, Escherichia coli, Animals, Amino Acid Sequence, Homologous Recombination, Plasmids
China, Base Sequence, Escherichia coli Proteins, Molecular Sequence Data, Mutant Chimeric Proteins, Microbial Sensitivity Tests, Ceftazidime, beta-Lactamases, Bacterial Proteins, Genes, Bacterial, Escherichia coli, Animals, Amino Acid Sequence, Homologous Recombination, Plasmids
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