Introduction Section I: Scientific Principles Epidemiology Enterovirus genetics Early events in infection Viral replication Transplantation and host cell shutoff Packaging and assembly Cell biology of enterovirus infections Host immune response to enterovirus infections Section II: Clinical Manifestations Poliomyelitis and vaccine strategies Perinatal enterovirus infections The febrile infant syndrome Respiratory infections Aseptic meningitis and encephalitis Myocarditis and dilated cardiomyopathy The possible role of enteroviruses in diabetes mellitus The possible role of enteroviruses in chronic neuromuscular diseases Section III: Diagnosis and Treatment Laboratory diagnosis Development of antiviral agents