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Science Signaling
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Science Signaling
Article . 2018 . Peer-reviewed
Data sources: Crossref
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Engineering allosteric regulation in protein kinases

Authors: David Pincus; Jai P. Pandey; Zoë A. Feder; Pau Creixell; Orna Resnekov; Kimberly A. Reynolds;

Engineering allosteric regulation in protein kinases

Abstract

Mutations in conserved surface regions facilitate the regulatory diversity of kinases.

Keywords

Binding Sites, Saccharomyces cerevisiae Proteins, Protein Conformation, Saccharomyces cerevisiae, Protein Engineering, Gene Expression Regulation, Enzymologic, Phosphates, Allosteric Regulation, Osmotic Pressure, Gene Expression Regulation, Fungal, Mutation, Mutagenesis, Site-Directed, Synthetic Biology, Mitogen-Activated Protein Kinases, Phosphorylation, Protein Kinases, Allosteric Site, Signal Transduction

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    26
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
Powered by OpenAIRE graph
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Top 10%
Average
Top 10%
bronze