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Science Signaling
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Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

descriptionPublicationkeyboard_double_arrow_right Article 21 Feb 2017 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Signaling, volume 10 (issn: 1945-0877, eissn: 1937-9145, Copyright policy )Funded by:NIH | D2 Receptor Induced Sensi..., NIH | Understanding adaptive si...
Authors: Tarsis F. Brust; Doungkamol Alongkronrusmee; Monica Soto-Velasquez; Tanya A. Baldwin; Zhishi Ye; Mingji Dai; Carmen W. Dessauer; +2 Authors

doi: 10.1126/scisignal.aah5381

pmid: 28223412

pmc: PMC5734633

Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties

Abstract

ST034307 is a selective AC1 inhibitor with analgesic activity.

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Keywords

Analgesics, Receptors, Opioid, mu, Pain, Hippocampus, Mice, HEK293 Cells, Adenylyl Cyclase Inhibitors, Cyclic AMP, Animals, Humans, Calcium Signaling, Adenylyl Cyclases

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    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 55
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
55
Top 10%
Top 10%
Top 10%
bronze
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