CXCL9 and CXCL10 bring the heat to tumors

Robin Reschke; Thomas F. Gajewski

Found an issue? Give us feedback

Science Immunologyarrow_drop_down

Science Immunology

Article . 2022 . Peer-reviewed

Data sources: Crossref

Science Immunology

Article . 2022

Data sources: Europe PubMed Central

CXCL9 and CXCL10 bring the heat to tumors

descriptionPublicationkeyboard_double_arrow_right Article 29 Jul 2022 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Immunology, volume 7 (eissn: 2470-9468,

Copyright policy )

Authors: Robin Reschke; Thomas F. Gajewski;

doi: 10.1126/sciimmunol.abq6509

pmid: 35867802

CXCL9 and CXCL10 bring the heat to tumors

- Summary
- Subjects
- Metrics

Abstract

CXCL9 and CXCL10 can be produced by antigen-presenting cells (dendritic cells or macrophages) and by tumor cells. Hoch et al. demonstrated that CXCL9 and CXCL10 co-localize with LAG3 + T cells expressing CCL4 or CXCL13 and contribute to the generation of a “hot” tumor microenvironment.

Related Organizations

University of Chicago
United States

Keywords

Chemokine CXCL10, Hot Temperature, Macrophages, T-Lymphocytes

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	188
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 0.1%