Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases
Copyright policy )Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases
Thiolutin, an inhibitor of the BRISC deubiquitinating enzyme complex, specifically and potently inhibits NLRP3 inflammasome activation.
- Tianjin University China (People's Republic of)
- Tianjin University China (People's Republic of)
- Protein Sciences United States
- State Key Laboratory of Proteomics China (People's Republic of)
- Beijing Proteome Research Center China (People's Republic of)
Lipopolysaccharides, Male, Mice, Knockout, Encephalomyelitis, Autoimmune, Experimental, Deubiquitinating Enzymes, Lactams, Inflammasomes, Interleukin-1beta, Primary Cell Culture, Interleukin-18, Diet, High-Fat, Fetal Blood, Disease Models, Animal, Mice, Non-alcoholic Fatty Liver Disease, Pregnancy, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Female
Lipopolysaccharides, Male, Mice, Knockout, Encephalomyelitis, Autoimmune, Experimental, Deubiquitinating Enzymes, Lactams, Inflammasomes, Interleukin-1beta, Primary Cell Culture, Interleukin-18, Diet, High-Fat, Fetal Blood, Disease Models, Animal, Mice, Non-alcoholic Fatty Liver Disease, Pregnancy, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Female
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