Igniting the flame in arthritis: C5aR2 controls endothelial transcytosis of C5a

descriptionPublicationkeyboard_double_arrow_right Article 24 May 2019 English Publisher:American Association for the Advancement of Science (AAAS)Journal:Science Immunology, volume 4 (eissn: 2470-9468,

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Authors: Jörg Köhl;

doi: 10.1126/sciimmunol.aax0352

pmid: 31076526

Igniting the flame in arthritis: C5aR2 controls endothelial transcytosis of C5a

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Abstract

C5aR2 transfers arthritic joint-derived C5a to the blood vessel endothelium to start C5aR1-driven neutrophilic inflammation. See related Research Article by Miyabe et al .

Related Organizations

University System of Ohio
United States
University of Lübeck
Germany
University of Cincinnati
United States
Cincinnati Children's Hospital Medical Center
United States
University of Cincinnati Medical Center
United States

Keywords

Inflammation, Neutrophils, Arthritis, Humans, Endothelium, Transcytosis, Receptors, Complement

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